08:45 Registration & coffee

09:15 Chairman’s welcome & opening address

Dr. Urs Lüthi
Senior Lab Head HTS
Actelion Pharmaceuticals Ltd., Switzerland

09:30 Management Collaborations: Compound management in a highly collaborative environment

• Two-way material & data exchange with multiple collaborators and distributed project teams
• Streamlining the database syncing process
• Ensuring data security for different IP backgrounds

Dr. Reiner Dieden
Director Analytical Sciences and Compound Management
UCB Pharma, Belgium

10:15 Single Chemistry for multiple applications such as PPI, epigenetics, and antiviral

• Design of mono- and bi-cyclic scaffolds with multiple points of attachment
• Is it possible to synthesize highly hydrophilic SAM/SAH mimetics and PPI inhibitors based on the same scaffolds?
• Design and synthesis of metabolically stable and rigid SAM/SAH mimetics based on glycomimetic spacers for epigenetics and antiviral applications
• Synthesis of drug-like molecules having 3-4 hydrophobic groups for PPI

Dr. Dmitry Genis
CEO
ASINEX

10:45 Refreshment break & networking

11:15 Clean-up: Compound and sample selection for an optimal screening library at Inventiva

• From a large collection to a high-quality screening set
• Clean-up process
• Workflow for quality-management of samples
• Chemical diversity

Dr. Jérôme Amaudrut
Senior Scientist in Computer Aided Drug Design
Inventiva, France

12:00 Logistics: Logistical challenges involved in the preparation of a global HTS library

• Assembly of a “Library Enhancement Work Group”
• Size, design, and quality matter - small, focussed libraries vs. big high-diverse collections
• Automation - additional hardware & software adaptations?
• Collaboration amongst global CL teams
• Impact of library enhancement on daily business
• Managing expectations - communication, communication, communication!
• Key challenges

Dr. Inge Moelans
Head Compound Logistics
Janssen Research & Development, Belgium

12:45 Panel discussion: The challenges of compound management

New ideas and innovation in compound management: How far are we from successful implementation of new management concepts?

Moderator:

Dr. Reiner Dieden
Director Analytical Sciences and Compound Management
UCB Pharma, Belgium

Panellists:

13:15 Networking luncheon

14:45 Global outsourcing: The BASF strategy for compound library extension

• Compound libraries in crop protection
• Different sources of compounds
• Management of globally outsourced activities
• Joining forces in partnership models

Dr. Oliver Sorgenfrei
Cooperation Management and Compound Acquisition
BASF SE, Germany

15:30 Challenges of an academic screening platform

• Integration of Liconic Kiwi Store with Tecan Evoware Station
• Presentation of different screening technologies used in the Screening Unit
• Measurements of compound properties
• Advice and interpretation of the screening data

Dr. Edgar Specker
Head of Compound Management
Leibniz Institute of Molecular Pharmacology, Germany

16:15 Refreshment break & networking

16:45 Enhanced value of HTS hits discovered on Actelion’s integrated screening platform

• Design strategy for Actelion’s compound libraries
• Check purity and solubility of screening hits by LC/MS, nephelometry and DLS
• Establish cutting-edge screening technologies: HCS, label-free detection
• Usage of appropriate cellular background: primary cells
• Development of innovative internal software solutions for data storage, analysis and mining
• Hit validation in secondary orthogonal assays and counter screens

Dr. Urs Lüthi
Senior Lab Head HTS
Actelion Pharmaceuticals Ltd., Switzerland

17:30 Design and production of diverse lead-like general screening library

• Design of general screening library
• How to enrich diversity of screening library with lead-like structures
• High throughput parallel array synthesis
• High throughput purification

Dr. Youichi Kimura
Senior Chief Researcher
Daiichi Sankyo Co., Ltd., Japan

18:15 End of day one

IQPC and the Novotel Berlin Am Tiergarten invite you to anevening reception with drinks. This is an excellent opportunity for you to meet the other attendees and make new business contacts.

18:45 Interactive Evening Event:

Register for an interactive evening event after the first conference day.

Have a guided walk in Berlin and a dinner with the other delegates and speakers in a pleasant ambience.